To make changes to an Apache HTTPD configuration file take effect without restarting the Apache service, you can use the apachectl command with the -k graceful option.
Here is an example of using the apachectl command to gracefully reload the Apache HTTPD configuration file:
sudo apachectl -k graceful
This command will reload the Apache HTTPD configuration file and apply the changes without interrupting any active connections or requests.
Keep in mind that the exact syntax and options for the apachectl command may vary depending on your specific Apache installation and configuration. It is always a good idea to refer to the official Apache documentation for detailed instructions and further information.